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Treatment of Baby Child weakness | Chote Bachon Ke Sokre ka Ilaj | Treatment of vomiting |


Hypotonia 2279
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Definition

Hypotonia, or severely decreased muscle tone, is seen primarily in children. Low-toned muscles contract very slowly in response to a stimulus and cannot maintain a contraction for as long as a normal muscle. Hypotonia is a symptom that can be caused by many different conditions.

Description

Hypotonia, also called floppy infant syndrome or
 infantile hypotonia, is a condition of decreased muscle tone. The low muscle tone can be caused by a variety of conditions and is often indicative of the presence of an underlying central nervous system disorder, genetic disorder, or muscle disorder. Muscle tone is the amount of tension or resistance to movement in a muscle. It is not the same as muscle weakness, which is a reduction in the strength of a muscle, but it can co-exist with muscle weakness. Muscle tone indicates the ability of a muscle to respond to a stretch. For example, if the flexed arm of a child with normal tone is quickly straightened, the flexor muscle of the arm (biceps) will quickly contract in response. Once the stimulus is removed, the muscle then relaxes and returns to its normal resting state. A child with low muscle tone has muscles that are slow to start a muscle contraction. Muscles contract very slowly in response to a stimulus and cannot maintain a contraction for as long as a normal muscle. Because low-toned muscles do not fully contract before they again relax, they remain loose and very stretchy, never achieving their full potential of sustaining a muscle contraction over time.
Hypotonic infants, therefore, have a typical "floppy" appearance. They rest with their elbows and knees loosely extended, while infants with normal muscle tone tend to have flexed elbows and knees. Head control is usually poor or absent in the floppy infant with the head falling to the side, backward, or forward. Infants with normal tone can be lifted by placing hands under their armpits, but hypotonic infants tend to slip between the hands as their arms rise unresistingly upward. While most children tend to flex their elbows and knees when resting, hypotonic children hang their arms and legs limply by their sides. Infants with this condition often lag behind in reaching the fine and gross motor developmental milestones that enable infants to hold their heads up when placed on the stomach, balance themselves, or get into a sitting position and remain seated without falling over. Hypotonia is also characterized by problems with mobility and posture, lethargy, weak ligaments and joints, and poor reflexes. Since the muscles that support the bone joints are so soft, there is a tendency for hip, jaw, and neck dislocations to occur. Some hypotonic children also have trouble feeding and are unable to suck or chew for long periods. Others may also have problems with speech or exhibit shallow breathing. Hypotonia does not, however, affect intellect.

Demographics

No demographic information as of 2004 was available for hypotonia, since it is a symptom of an underlying disorder. However, a study conducted in year 2000 by the University of Illinois provides some insights. The study followed 243 infants with hypotonia for three to seven years. By the age of three, about 30 percent had minimal problems and 46 percent had significant impairments, while 24 percent of the infants were normal. Hypotonic infants who matured into children with minimal disabilities were highly likely to have poor motor coordination at age three (78%). About 25 percent had learning problems or language delay ; 20 percent had borderline cognition or attention deficits; and 66 percent had two or more of these characteristics.

Causes and symptoms

Hypotonias are often of unknown origin. Scientists believe that they may be caused by trauma; environmental factors; or by other genetic, muscle, or central nervous system disorders. The National Institutes of Health list the following common causes of hypotonia:
  • Down syndrome: a chromosome abnormality, usually due to an extra copy of the twenty-first chromosome.
  • Myasthenia gravis: a neuromuscular disorder characterized by variable weakness of voluntary muscles, which often improves with rest and worsens with activity. The condition is caused by an abnormal immune response.
  • Prader-Willi syndrome: a congenital disease characterized by obesity , severe hypotonia, and decreased mental capacity
  • Kernicterus: also called Rh incompatibility, a condition that develops when there is a difference in Rh blood type between that of the mother (Rh negative) and that of the fetus (Rh positive).
  • Cerebellar ataxia: a movement disorder which with its sudden onset, often following an infectious viral disease, causes hypotonia.
  • Infant botulism : a type of botulism, in which Clostridium botulinum bacteria grow within an infant's digestive tract, producing a toxin which is potentially life-threatening.
  • Familial dysautonomia: also called Riley-Day syndrome, an inherited disorder that affects the function of nerves throughout the body.
  • Marfan syndrome: an inherited disorder of connective tissue (tissue that adds strength to the body's structures), affecting the skeletal system, cardiovascular system, eyes, and skin.
  • Muscular dystrophy: a group of disorders characterized by progressive muscle weakness and loss of muscle tissue.
  • Achondroplasia: a disorder of bone growth that causes the most common type of dwarfism.
  • Trisomy 13: a syndrome associated with the presence of a third number 13 chromosome.
  • Sepsis: a severe, life-threatening illness caused by overwhelming infection of the bloodstream by toxin-producing bacteria.
  • Aicardi syndrome: a rare genetic disorder characterized by infantile spasms (jerking), absence of the corpus callosum (the connection between the two hemispheres of the brain), mental retardation , and lesions of the retina of the eye or optic nerve.
  • Canavan disease: an inherited metabolic disorder characterized by degeneration of the white matter of the brain.
  • Congenital hypothyroidism : a disorder that results from decreased thyroid hormone production.
  • Hypervitaminosis D: a condition that appears several months after excessive doses of vitamin D are administered.
  • Krabbe disease: an inherited disorder characterized by a deficiency of the enzyme galactosylcereamidase, resulting in destruction of myelin, the fatty material that surrounds and insulates many of the nerves.
  • Metachromatic leukodystrophy: an inherited disease characterized by the absence of the enzyme arylsulfatase A, which causes a material called cerebroside sulfate to accumulate in cells, which is toxic to cells, especially to the cells of the nervous system.
  • Methylmalonic academia: an inherited metabolic disorder, usually diagnosed in infancy, which causes the accumulation of methylmalonic acid in the body and can lead to severe metabolic disturbances.
  • Rickets: a childhood disorder involving softening and weakening of the bones, primarily caused by lack of vitamin D, calcium, or phosphate.
  • Spinal muscular atrophy type 1 (Werdnig-Hoffman): a group of inherited diseases causing progressive muscle degeneration and weakness, eventually leading to death.
  • Tay-Sachs disease: a genetic disorder found predominantly in Ashkenazi Jewish families results in early death.
  • Vaccine reaction: any injury or condition that occurs as a result of a vaccination.
The following are common symptoms associated with hypotonia. Each child may experience different symptoms, depending on the underlying cause of the hypotonia:
  • decreased muscle tone; muscles feel soft and doughy
  • ability to extend limb beyond its normal limit
  • failure to acquire motor skill developmental milestones (such as holding head up without support from parent, rolling over, sitting up without support, walking)
  • feeding problems (inability to suck or chew for prolonged periods)
  • shallow breathing
  • mouth hangs open with tongue protruding (underactive gag reflex)

When to call the doctor

Normally developing children tend to develop motor skills, posture control, and movement skills by a given age. Motor skills are divided into two categories. Gross motor skills include the ability of an infant to lift its head while lying on the stomach, to roll over from its back to its stomach. Normally, by a given age, a child develops the gross motor skills required to get into a sitting position and remain seated without falling over, crawl, walk, run, and jump. Fine motor skills include the ability to grasp, transfer an object from one hand to another, point out an object, follow a toy or a person with the eyes, or to feed oneself. Hypotonic children are slow to develop these skills, and parents should contact their pediatrician if they notice such delays or if their child appears to lack muscle control, especially if the child previously seemed to have normal muscle control.

Diagnosis

Hypotonia is normally discovered within the first few months of life. Since it is associated with many different underlying disorders, the doctor will accordingly seek to establish a family history as well as the child's medical history. A physical examination will be performed, usually including a detailed nervous system and muscle function examination. The latter may be performed with instruments, such as lights and reflex hammers, and usually does not cause any pain to the child. Most of the disorders associated with hypotonia also cause other symptoms that, when taken together, suggest a specific disorder and cause for the hypotonia. Specific diagnostic tests used will vary depending on the suspected cause of the hypotonia. Typical medical history questions include:
  • When was the hypotonia first noticed?
  • Was it present at birth?
  • Did it start suddenly or gradually?
  • Is the hypotonia always the same or does it seem worse at certain times?
  • Is the child limp all over or only in certain areas?
  • What other symptoms are present?
The following diagnostic tests may also be used:
  • Blood tests.
  • Creatine kinase (CK) test: elevated CK level in blood indicating muscles are damaged or degenerating.
  • Computerized tomography scan (CT scan): a diagnostic imaging procedure that uses a combination of x-rays and computer technology to produce cross-sectional images. CT scans help physicians evaluate bone and muscle structures.
  • Magnetic resonance imaging (MRI): a diagnostic procedure that uses a combination of large magnets, radio frequencies, and a computer to produce detailed images of organs and structures within the body.
  • Electromyogram (EMG): a test used to evaluate nerve and muscle function.
  • Electroencephalogram (EEG): a test that measures the electrical activity in the brain. An EEG measures brain waves through small button electrodes that are placed on the child's scalp.
  • Spinal tap: also called lumbar puncture, measures the amount of pressure in the spinal canal and/or to remove a small amount of cerebral spinal fluid ( CSF ) for testing. Cerebral spinal fluid bathes the brain and spinal cord.
  • Karyotype: a test that performs a chromosomal analysis from a blood test, used to determine whether the hypotonia is the result of a genetic disorder.
  • Muscle biopsy: a sample of muscle tissue removed and examined under a microscope. Hypotonia can be assessed because muscle fibers have a smaller diameter than that of normal muscle.

Treatment

When hypotonia is caused by an underlying condition, that condition is treated first, followed by symptomatic and supportive therapy for the hypotonia. Physical therapy can improve fine motor control and overall body strength. Occupational and speech-language therapy can help breathing, speech, and swallowing difficulties. Therapy for infants and young children may also include sensory stimulation programs. Specific treatment for hypotonia is determined by the child's physician based on the following:
  • the child's age, overall health, and medical history
  • the extent of the condition
  • the underlying cause of the condition
  • the child's tolerance for specific medications, procedures, or therapies
  • expectations for the course of the condition
  • parent opinion or preference
No specific treatment is required to treat mild congenital hypotonia, but children with this problem may periodically need treatment for common conditions associated with hypotonia, such as recurrent joint dislocations. Treatment programs to help increase muscle strength and sensory stimulation programs are developed once the cause of the child's hypotonia is established. Such programs usually involve physical therapy through an early intervention or school-based program among other forms of therapy.
Hypotonic children are often treated by one or more of the following specialists:

  • Developmental pediatrician: a pediatrician with specialized training in children's social, emotional, and intellectual development as well as health and physical growth. He or she may conduct a developmental assessment which will determine any delays the child has and to what extent the delay is present.
  • Neurologist: a physician who has trained in the diagnosis and treatment of nervous system disorders, including diseases of the brain, spinal cord, nerves, and muscles. Neurologists perform neurological examinations of the nerves of the head and neck; muscle strength and movement; balance, ambulation, and reflexes; and sensation, memory, speech, language, and other cognitive abilities.
  • Geneticist: a specialist in genetic disorders. He or she starts with the detailed history of the family's background, looks at the child's features and orders blood tests to look at the 46 chromosomes and possibly at specific genes on those chromosomes.
  • Occupational therapist (OT): a professional who has specialized training in helping to develop mental or physical skills that help accomplish daily living activities, with careful attention to enhancing fine motor skills. In a developmental assessment, the occupational therapist assesses the child's fine motor skills, coordination, and age-appropriate self-help skills (eating with utensils, dressing, etc.).
  • Physical therapist (PT): a professional trained in assessing and providing therapy to treat developmental delays using methods such as exercise , heat, light, and massage. In a developmental assessment, the physical therapist assesses the ability and quality of the child's use of legs, arms, and complete body by observing the display of specific gross motor skills as well as observing the child in play.
  • Speech/language pathologist (SLP): a professional who is trained in assessing and treating problems in communication. Some SLPs are also trained to work with oral/motor problems, such as swallowing, and other feeding difficulties resulting from hypotonia.

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